Highlights From The Comments On Zulresso
Thanks to everyone who commented on Zounds! It’s Zulresso and Zuranolone and on the followup Progesterone Megadoses Might Be A Cheap Zulresso Substitute. I’m constantly impressed by the expertise of commenters here and on how much better the biomedical comment threads are compared to some of the others. Among the things I learned: — Metacelsus (who writes the blog De Novo) doubts the price estimates I posted:
He also wrote a longer blog post about the science of progesterone here. — Douglas (who writes the blog A Mindful Monkey) clears up some mechanism details I missed:
— Zutano (whose name makes them sound like another novel drug in this class!) debunks my urban legend that the -pam at the end of benzo names (eg “diazepam”) stands for positive allosteric modulator:
— Jimmy Steier on Twitter gives more information on tolerance development:
This paper confirms that women with PMDD or PPD (but not other women) get tolerance to allopregnanolone within the normal course of the menstrual cycle or pregnancy. There’s actually a study showing that these women get less effect from benzos during this time, since the allopregnanolone and benzos have cross-tolerance! — Thomas Reilly has a new blog Rational Psychiatry where he’s written up some more info on premenstrual dysphoria and progesterone. For example:
And:
See here for further discussion of the failed trial. — Benjamin Jolley (who writes the blog Ramblings Of A Pharmacist), has a couple interesting comments:
— Many commenters took progesterone for one reason or another and said it made them feel either more or less anxious; the thread starts here and keeps going for a bit. For example, Reader:
And Angela:
Leah Libresco Sargent (who writes the blog Other Feminisms):
— Slimepriestess on side effects:
Yeah, this has me confused about why pregnancy isn’t more sedating than it is. In general, I appreciated everyone’s progesterone-related thoughts. I spent most of my career in a clinic with ten psychiatrists. Nine of them were women, the tenth one was me. You can imagine who all the women with female-hormone-related problems didn’t want to see, so my hands-on experience here is more limited than usual. Thanks for filling this gap in my education! You’re a free subscriber to Astral Codex Ten. For the full experience, become a paid subscriber. |
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Justice Creep
Wednesday, March 16, 2022
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Mantic Monday 3/14/22
Monday, March 14, 2022
More Ukraine warcasting, nuclear war risk, forecasters vs. experts
Open Thread 215
Sunday, March 13, 2022
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Progesterone Megadoses Might Be A Cheap Zulresso Substitute
Thursday, March 10, 2022
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Advice For Unwoke Academic?
Thursday, March 10, 2022
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