EpiPen Alternative, Brazil Plane Crash, and Regional Cocktails

Facts, without motives. ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌
Facts, without motives.

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Good morning. It's Saturday, Aug. 10, and in this weekend edition, we're covering a needle-free alternative to EpiPen, a deadly plane crash in Brazil, and much more. First time reading? Join over 3.7 million readers. Sign up here.

 

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One Big Headline
 

FDA Approves Neffy

The US Food and Drug Administration yesterday approved the first-ever nasal spray to treat potentially severe allergic reactions. The spray, sold under the brand name Neffy, provides a needle-free alternative to traditional injectable epinephrine products like EpiPen (first introduced in 1987). 

 

Neffy is designed for adults and children weighing at least 66 pounds and is administered as a single spray into one nostril. Studies showed Neffy achieved blood concentrations of epinephrine comparable to those from injections, along with similar physiological effects such as increased blood pressure and heart rate. Epinephrine (see overview), also known as adrenaline, is a hormone that helps stimulate the heart, relaxes muscles, and constricts blood vessels to improve breathing. It is used to help treat anaphylaxis, a life-threatening reaction to foreign substances in the body. 

 

Nearly 50 million Americans suffer from allergies. Each year, more than 30,000 Americans visit emergency rooms due to anaphylaxis, with more than 2,000 hospitalizations and over 100 deaths (see data). 

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Quick Hits
 

Plane crashes in Brazil, killing all 61 people aboard.

The passenger plane, operated by Brazilian airline VoePass, crashed outside its destination of Sao Paulo. Authorities are still investigating the cause of the incident as of this writing. Video footage captured by a bystander shows a plane spiraling toward the ground in the city of Vinhedo; see footage here (warning—sensitive content). 

 

Sha’Carri Richardson and US women's 4x100 relay team win gold. 

The victory is Richardson's first Olympic gold medal and teammate Gabby Thomas's second. The US men's 4x100 relay team was disqualified, extending a 20-year streak without an Olympic medal. Separately, the US women's basketball team beat Australia to advance to the final, marking their eighth consecutive Olympic gold medal game. The US will face France Sunday. See latest medal count here.

 

Remnants of Debby pummel Mid-Atlantic and Northeast.

Tornado and flood watches are in place through the weekend from the Carolinas to New England, with the weather service warning of up to 25 inches of rain in some areas. The death toll has risen to at least nine people. Debby made landfall in the US as a Category 1 hurricane on Florida's Gulf Coast Monday and as a tropical storm off South Carolina's coast Wednesday. It was downgraded Friday to a post-tropical storm with winds of 30 mph. Track Debby here.

 

Third suspect arrested in alleged terror plot at Taylor Swift concert.

An 18-year-old man was taken into custody a day after two other suspects were arrested for allegedly plotting a terrorist attack near the concert venue in Vienna, Austria. Swift canceled her three upcoming Eras Tour shows in the city, where roughly 195,000 people had been expected. At least one of the suspects is believed to be affiliated with ISIS. 

 

Microsoft warns Iran hackers appear to target US election.

Iran is ramping up online activity that appears intended to influence the US election, Microsoft announced Friday. Iran's online activity includes propping up US-based news sites to target voters from opposite political parties to sow division and targeting a presidential campaign with a phishing attack (see 101). Iranian groups were also found to have impersonated US activists. See Microsoft's findings here.

 

Study finds serotonin changes how people react to adverse outcomes.

According to the study, people with increased serotonin levels were less sensitive to negative information, such as losing money in a game, and were able to control their behaviors better when encountering such moments. The findings shed light on serotonin's role beyond boosting positive moods.

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Humankind
 

Minnesota bus driver gives her shoes to an unhoused passenger in need. (More

 

College students clean up plastic pollution from Alaska's remote beaches. (More)

 

Man runs into Park Fire evacuation zone to rescue stranded dogs, puppies. (More

 

UK community comes together to rebuild mosque damaged by rioters. (More)

 

A 19-year-old vies for record solo flight to raise money for cancer research. (More)

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Humankind(ness)
 

Today, we're sharing a story from reader Pat P. in Orting, Washington

 

"Recently my husband and I were at our local grocery store, and I asked at the meat/fish display if they had any catfish. After talking with two separate workers, who pretty much just said 'if you don't see it, it's not here,' an older gentleman approached us and asked if he could help. I explained we were looking for catfish. He took us right over to the frozen fish area, and pulled out a package of prewrapped catfish. It did not say how many pieces were in the bag, but I did mention that I had hoped it was an even number, because there was just the two of us."

 

"He then proceeded to open the package, and there were only three. Just as we discovered this, the kind gentleman opened a second package and pulled out an extra piece of fish, put it in our bag to make it four pieces and told us that if we had trouble checking out, just tell the cashier to talk to the 'Fish Manager.' An act of kindness that you could tell was his natural treatment of people. A small act, but carried a memorable impression."

 

What act(s) of kindness did you experience this week? Tell us here.

Etcetera
 

Bookkeeping

> Nvidia accused of scraping 80 years worth of videos daily to train AI models.

> Celebrities estimated to pay upward of $60K for a complete set of veneers 

> A teacher spent 1,800 hours building the hovercraft of his childhood dreams.

 

Browse 

> A tour of America's regional cocktails

> Visualizing what happens when our emotions combine.

Groundhog found in claw machine game.

> Introducing the world's first intelligent robotic whale shark

> Why "run" is the most complicated English word

 

Listen 

> Why does every creature on the planet sleep and what happens when we don't?

 

Watch 

> How AI could help humans talk to animals.

> Why did people back in the day wear powdered wigs?

> Architect breaks down most common college campus designs.

 

Long Read 

> Agent Zo: the woman who left Britain to parachute into Nazi-occupied Poland.

> How poetry was an official Olympic event for nearly 40 years—until it wasn't.

 

Most Clicked This Week: Whale photobombs Olympic surfing competition.

 

Historybook: The Louvre opens in Paris (1793); Smithsonian Institution established (1846); Former President Herbert Hoover born (1874); "Hunger Games" author Suzanne Collins born (1962); Jeffrey Epstein found dead in jail while awaiting trial on sex trafficking charges (2019).

"Keep good company—that is, go to the Louvre."

- Paul Cézanne

Why 1440? The printing press was invented around the year 1440, spreading knowledge to the masses and changing the course of history. More facts: In every day, there are 1,440 minutes. We’re here to make each one count.

 

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Ukraine's Incursion, Noah Lyles, and Microwave Microbiomes

Friday, August 9, 2024

Facts, without motives. ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

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Saturday, August 3, 2024

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Wednesday, July 31, 2024

Facts, without motives. ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

England Stabbing, California Fire, and Sleep Training

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Facts, without motives. ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

Venezuela Election, Olympic Tally, and a Domino Chain

Monday, July 29, 2024

Facts, without motives. ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

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