The Conversation - How to reverse age-related decline

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Lead story

They seem like unmovable truths: the sky is blue, squares are rectangles, and every passing year drags your body kicking and screaming down a path of inexorable decline.

Your risk of developing diseases like cancer, heart disease and neurodegenerative disorders increases as you age. This happens, in part, because your body’s ability to perform the thousands of chemical reactions that allow you to function optimally – collectively called your metabolism – falls out of balance.

While you can’t fully escape the effects of time, researchers are finding that there may be ways to slow down its harms – and maybe even reverse some of them.

Melanie McReynolds is a scientist at Penn State who studies the relationship between metabolism, stress and aging. Her research, published yesterday, explains how a cancer drug could possibly be repurposed to restore proper metabolism in brain cells and cognitive function in mice.

“Our findings suggest that targeting metabolism has the potential to not only slow neurological decline but also to reverse the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and dementia,” she writes.

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Vivian Lam

Associate Health and Biomedicine Editor

Aging is inevitable, but there are some ways to slow down decline. Dimitri Otis/Stone via Getty Images

What links aging and disease? A growing body of research says it’s a faulty metabolism

Melanie R. McReynolds, Penn State

Targeting the key players that help your body regulate metabolism could reverse disease progression, including cognitive decline related to Alzheimer’s disease.

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