How FDA warnings on antidepressants backfired

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Anyone who has sought out treatment for depression in a loved one – or for themself – can relate to the fears and uncertainty surrounding the possible outcomes. Could medication make things worse? What about unexpected side effects? When it comes to adolescents, these types of decisions can feel even weightier.

So when the FDA began issuing warnings in 2003 that young people could face an increased risk of suicidal thoughts and behavior after taking antidepressants – based on tenuous research – it had a chilling effect on all mental health care, including the use of such medication for adolescents and young adults with depression.

Stephen Soumerai and Ross Koppel, who research the effects of health policies on patient safety, have documented nearly two decades’ worth of data showing how these messages, which were intended to prevent harm, did just the reverse: They contributed to a reduction in detection of suicidal behavior and a dramatic rise in youth suicides.

Also today:

Amanda Mascarelli

Senior Health and Medicine Editor

The link between antidepressant use and increases in suicidal thoughts or behaviors among treated youth is unproven. FatCamera/E+ via Getty Images

After the FDA issued warnings about antidepressants, youth suicides rose and mental health care dropped

Stephen Soumerai, Harvard University; Ross Koppel, University at Buffalo

A well-intentioned public health message has had serious negative impacts on the treatment of young people for depression.

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